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Selective CCR5 antagonist
Inhibits hepatitis C viral life cycle; also α-crystallin (cryAB) chaperone
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
Toll-like receptor 7 (TLR7) agonist
Potent and selective VPAC2 agonist
Specific inhibitor of NF-κB activation
Non-selective P2 antagonist
Selective PC-PLC inhibitor
Toll-like receptor 7 (TLR7) agonist
Core binding factor inhibitor; attenuates hematopoiesis
mSTING agonist; induces antitumor immunological responses
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide prodrug
α-glucosidase I and II inhibitor; also inhibits ceramide-specific glycosyltransferases and exhibits broad spectrum antiviral activity
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
Reverse transcriptase inhibitor
DNA polymerase α, δ and ε inhibitor
HIV-1 and HIV-2 protease inhibitor
Potent and selective HIV-1 and HIV-2 protease inhibitor
Influenza virus neuraminidase inhibitor; antiviral prodrug
Coronavirus PLpro inhibitor
Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
BLT1/BLT2 receptor agonist and potent chemotactic factor
p53 activator. Also ROS scavenger
Potent HIV-1 protease inhibitor
Blocks eIF4E activity; antiviral guanosine analog
2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
Potent and selective PI 4-kinase IIIβ inhibitor
Potent and selective CCR5 and CCR2 chemokine receptor antagonist
Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
Antiflaviviral; active against Zika, Dengue and Hepatitis C viruses
Potent and selective hepatitis B virus inhibitor
Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral
Highly potent and selective HIV-1 protease inhibitor
Potent influenza virus neuraminidase inhibitor
Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
Viral RNA polymerase inhibitor
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral
Coronavirus Mpro inhibitor
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleoside
Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective
Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral
Potent and high affinity H2 biased inverse agonist
Potent and selective herpes simplex virus (HSV) helicase primase inhibitor
Inhibits coronavirus RNA replication; impairs double membrane vesicle (DMV) formation