Tenofovir
Chemical Name: (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
Purity: ≥99%
Biological Activity
Tenofovir is a selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Ternary polysaccharide complexes: Colloidal drug delivery systems stabilized in physiological media
D Wu, A Ensinas, B Verrier, A Cuvillier, G Champier, S Paul, T Delair
Carbohydr Polym, 2017;172(0):265-274. -
Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine.
Tsai et al.
Science, 1995;270:1197 -
9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques.
Van Rompay et al.
Antimicrob.Agents Chemother., 1996;40:2586 -
Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine.
Suo et al.
J.Biol.Chem., 1998;273:27250
Product Datasheets
Citation for Tenofovir
The citations listed below are publications that use Tocris products. Selected citations for Tenofovir include:
1 Citation: Showing 1 - 1
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ATP/ADP biosensor organoids for drug nephrotoxicity assessment.
Authors: Joseph V Et al.
Front Cell Dev Biol 2023;11:1138504
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