Home / Chemokine Receptor Antagonists / TAK 779

TAK 779

Catalog #: 4340 Datasheet
Catalog # Availability Size / Price Qty
4340/10
4340/50
TAK 779 | CAS No. 229005-80-5 | Chemokine Receptor Antagonists
1 Image
Description: Potent and selective CCR5 and CCR2 chemokine receptor antagonist

Chemical Name: N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC50 values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC50 = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.

Technical Data

M.Wt:
531.13
Formula:
C33H39N2O2.Cl
Solubility:
Soluble to 10 mM in water and to 5 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
229005-80-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TAK 779

There are currently no reviews for this product. Be the first to review TAK 779 and earn rewards!

Have you used TAK 779?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.