D609
Chemical Name: O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate
Purity: ≥98%
Biological Activity
D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Also inhibits sphingomyelin synthase. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature.
Adibhatla et al.
Neurochem.Res., 2012;37:671 -
The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C.
Amtmann
Drugs Exp.Clin.Res., 1996;22:287 -
Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609).
Tschiakowsky et al.
Br.J.Pharmacol., 1994;113:664 -
D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant.
Zhou et al.
J.Pharmacol.Exp.Ther., 2001;298:103
Product Datasheets
Citations for D609
The citations listed below are publications that use Tocris products. Selected citations for D609 include:
5 Citations: Showing 1 - 5
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Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Authors: Pitt Et al.
Mol Biol Cell 2017;28:2623
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Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model.
Authors: Sovadinova Et al.
J Pharmacol Exp Ther 2015;10:e0124454
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Francisella tularensis LVS induction of prostaglandin biosynthesis by infected macrophages requires specific host phospholipases and lipid phosphatases.
Authors: Navratil Et al.
Infect Immun 2014;82:3299
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Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs.
Authors: Pastor Et al.
J Lipid Res 2014;55:966
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Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems.
Authors: Upham Et al.
Environ Health Perspect 2009;117:545
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