MPro N3
Chemical Name: N-[(5-Methyl-3-isoxazolyl)carbonyl]-L-alanyl-L-valyl-N-[(1S,2E)-4-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-4-(phenylmethoxy)-2-buten-1-yl]-L-leucinamide
Purity: ≥98%
Biological Activity
MPro N3 is a coronavirus main protease (Mpro) inhibitor (respective IC50 values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro). Inhibits viral cell infection in an MHV plaque reduction assay. Also inhibits SARS-CoV-2 viral cell entry in a plaque reduction assay (IC50 = 16.8 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors.
Jin et al.
Nature., 2020;582:289 -
Design of wide-spectrum inhibitors targeting coronavirus main proteases.
Yang et al.
PLoS.One., 2005;10
Product Datasheets
Citation for MPro N3
The citations listed below are publications that use Tocris products. Selected citations for MPro N3 include:
1 Citation: Showing 1 - 1
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Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates.
Authors: Ghislaine Et al.
Nat Commun 2021;12:6786
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