Entecavir
Chemical Name: 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
Purity: ≥98%
Biological Activity
Entecavir is a potent and selective hepatitis B virus reverse transcriptase inhibitor (EC50 = 3 nM); guanine analog. Inhibits hepatitis B virus replication in HepG2.2.15 cells. Displays selectively over HCMV, HSV-1, VZV, HIV and influenza (EC50 values are 15, 32, 30-60, >10 and >80 μM respectively). Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
Bisacchi et al.
Bioorganic & Medicinal Chemistry Letters, 1997;7:127 -
Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus.
Innaimo et al.
Antimicrob. Agents Chemother., 1997;41:1444
Product Datasheets
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