Ritonavir
Chemical Name: 5-Thiazolylmethyl (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoate
Purity: ≥98%
Biological Activity
Ritonavir is a HIV-1 and HIV-2 protease inhibitor (EC50 values are 0.022-0.13 and 0.16 μM, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable. When used in combination with lopinavir, improves outcome in an animal model of MERS-CoV infection.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.
Kempf et al.
Proc.Natl.Acad.Sci.U.S.A., 1995;92:2484 -
Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy.
Kempf et al.
J.Med.Chem., 1998;41:602 -
Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients.
Zeldin et al.
J.Antimicrob.Chemother., 2004;53:4 -
Treatment with Lopinavir/Ritonavir or Interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset.
Chan et al.
J.Infect.Dis., 2015;12:1904
Product Datasheets
Citation for Ritonavir
The citations listed below are publications that use Tocris products. Selected citations for Ritonavir include:
1 Citation: Showing 1 - 1
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The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.
Authors: Matthew B Et al.
Sci Transl Med 2021;13
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