ABX 464
Chemical Name: 8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Purity: ≥98%
Biological Activity
ABX 464 is an HIV RNA splicing modulator; it selectively enhances the splicing of HIV RNA in infected human PBMCs and inhibits viral replication, with no global effect on cellular splicing. ABX 464 inhibits replication of HIV strains harboring mutations associated with drug-resistance. ABX 464 binds the cap binding complex (CBC) and upregulates miR-124 expression in vitro and decreases expression of miR-124 target genes, MCP-1, CXCL-1, SERPIN-E1 in macrophages. It also decreases the number of Th17 cells, as well as IL-6 soluble receptor in CD4+ T cells. In HIV infected humanized mice, treatment with ABX 464 reduces viral load. Anti-inflammatory.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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