25-Hydroxycholesterol
Chemical Name: Cholest-5-ene-3β,25-diol
Purity: ≥95%
Biological Activity
25-Hydroxycholesterol is an antiviral. Stimulates expression of miR-185 microRNA which inhibits the hepatitis C virus life cycle via inhibition of cholesterol biosynthesis and virus cell membrane fusion. Also α-crystallin (cryAB) chaperone (Kd = 10.1 μM). Blocks α-crystallin aggregation and partially reverses cataract formation by binding and stabilizing soluble forms of cryAB in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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MicroRNAs regulate the immunometabolic response to viral infection in the liver.
Singaravelu et al.
Nat.Chem.Biol., 2015;11:988 -
Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models.
Makley et al.
Science, 2015;350:674
Product Datasheets
Citations for 25-Hydroxycholesterol
The citations listed below are publications that use Tocris products. Selected citations for 25-Hydroxycholesterol include:
2 Citations: Showing 1 - 2
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Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types.
Authors: Judith Et al.
iScience 2022;25:103848
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Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production.
Authors: Keith S Et al.
Sci Rep 2021;11:16347
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