Remdesivir

Catalog #: 7226
2 Citations Datasheet

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7226/50
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Remdesivir | CAS No. 1809249-37-3 | RNA/DNA Polymerase Inhibitors

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Description: Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide prodrug

Alternative Names: GS-5734

Chemical Name: 2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate

Purity: ≥98%

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Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Remdesivir is a viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form, GS 441524 (Cat. No. 7227). Exhibits activity against a range of RNA viruses in vitro (EC₅₀ values are 0.019, 0.07, 0.07 - 0.34, 0.086 - 0.14, and 23.15 μM against RSV, SARS-CoV, MERS-CoV, EBOV and SARS-CoV-2, respectively). Exhibits antiviral efficacy in animal models of MERS-CoV and EBOV infection.

Technical Data

M.Wt:

602.58

Formula:

C₂₇H₃₅N₆O₈P

Solubility:

Soluble to 100 mM in DMSO and to 20 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1809249-37-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2replication in vitro.
Choy et al.
Antiviral Res., 2020;178:104786
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
Sheahan et al.
Nat.Commun., 2020;11:222
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
Warren et al.
Nature, 2016;531:381

Product Datasheets

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Citations for Remdesivir

The citations listed below are publications that use Tocris products. Selected citations for Remdesivir include:

2 Citations: Showing 1 - 2

A proteome-scale map of the SARS-CoV-2-human contactome.
Authors: Marc Et al.
Nat Biotechnol 2023;41:140-149
Putative COVID-19 therapies imatinib, lopinavir, ritonavir, and ivermectin cause hair cell damage: A targeted screen in the zebrafish lateral line.
Authors: Allison B Et al.
Front Cell Neurosci 2022;16:941031

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