Maraviroc
Chemical Name: 4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl- 5-methyl-4H-1,2,4-triazol-4-yl)- 8-azabicyclo[3.2.1]oct-8-yl]-1- phenylpropyl}cyclohexanecarboxamide
Purity: ≥99%
Biological Activity
Maraviroc is a selective CCR5 antagonist; displays potent anti-HIV-1 activity. Prevents the interaction of HIV-1 gp120 and CCR5 (IC50 = 6.4 nM), inhibiting HIV-1 entry. Exhibits antinociceptive effects in a rat model of neuropathic pain. Also inhibits CCL3 (MIP-1α) binding to CCR5. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Simultaneous blockade of IL-6 and CCL5 signaling for synergistic inhibition of triple-negative breast cancer growth and metastasis
K Jin, NB Pandey, AS Popel
Breast Cancer Res., 2018;20(1):54. -
Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
Lourenco S, Teixeira V, Kalber T, Jose R, Floto R, Janes S
J Immunol, 2015;194(7):3463-74. -
C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation
CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber
Elife, 2018;7(0):. -
Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
Nat Commun, 2014;5(0):4715. -
Biased signaling at chemokine receptors.
Corbisier J, Gales C, Huszagh A, Parmentier M, Springael J
J Biol Chem, 2015;290(15):9542-54. -
Astrocytic orosomucoid-2 modulates microglial activation and neuroinflammation
M Jo, JH Kim, G Song, M Seo, E Mi Hwang, K Suk
J. Neurosci, 2017;0(0):. -
Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity.
Dorr et al.
Antimicrob.Agents Chemother., 2005;49:4721 -
New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection.
Garcia-Perez et al.
J.Biol.Chem., 2011;286:4978 -
Maraviroc reduces neuropathic pain through polarization of microglia and astroglia - Evidence from in vivo and in vitro studies.
Piotrowska et al.
Neuropharmacology, 2016;S0028-3908:30164 -
Fresh from the pipeline - mara.
Kuritzkes et al.
Nat.Rev.Drug Discov., 2008;7:15
Product Datasheets
Citations for Maraviroc
The citations listed below are publications that use Tocris products. Selected citations for Maraviroc include:
7 Citations: Showing 1 - 7
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Innate αβ T cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming.
Authors: Hundeyin Et al.
Cancer Discov 2019;
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Water Filtered Infrared A and Visible Light (wIRA/VIS) Irradiation Reduces Chlamydia trachomatis Infectivity Independent of Targeted Cytokine Inhibition.
Authors: Kuratli Et al.
Front Microbiol 2018;9:2757
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Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis.
Authors: Kim
Sci Rep 2018;8:7499
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Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop.
Authors: Lin Et al.
Oncotarget 2017;8:110426
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Maraviroc reduces neuropathic pain through polarization of microglia and astroglia - Evidence from in vivo and in vitro studies.
Authors: Piotrowska Et al.
Neuropharmacology 2016;S0028-3908:30164
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The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory.
Authors: Marciniak Et al.
Sci Signal 2015;5:15862
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Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
Authors: Lourenco Et al.
J Immunol 2015;194:3463
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