Imiquimod
Chemical Name: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
Purity: ≥99%
Biological Activity
Imiquimod is an immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR7) agonist; stimulates proinflammatory cytokine production and activates NF-κB.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation
R Matsumoto, T Dainichi, S Tsuchiya, T Nomura, A Kitoh, MS Hayden, KJ Ishii, M Tanaka, T Honda, G Egawa, A Otsuka, S Nakajima, K Sakurai, Y Nakano, T Kobayashi, Y Sugimoto, K Kabashima
JCI Insight, 2018;3(15):. -
The pharmacology of endosomal TLR agonists in viral disease.
Averett et al.
Biochem.Soc.Trans., 2007;35:1468 -
A review of the applications of imiquimod: a novel immune response modifier.
Syed et al.
Exp.Opin.Pharmacother., 2001;2:877 -
The antitumoral mode of action of imiq. and other imidazoquinolines.
Schon and Schon
Curr.Med.Chem., 2007;14:681
Product Datasheets
Citations for Imiquimod
The citations listed below are publications that use Tocris products. Selected citations for Imiquimod include:
4 Citations: Showing 1 - 4
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Presence of TRPA1 Modifies CD4+/CD8+ T Lymphocyte Ratio and Activation.
Authors: Zoltan Et al.
Pharmaceuticals (Basel) 2022;15
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Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.
Authors: Jian Et al.
Nat Commun 2021;12:4546
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Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip.
Authors: Qian Et al.
Elife 2020;9
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Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways.
Authors: Erick M Et al.
Cell Rep 2020;30:4399-4417.e7
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