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Inhibits trypsin-like/cysteine proteases
Selective and high affinity cathepsin D inhibitor
Competitive serine protease inhibitor
Non-selective protease inhibitor; also blocks anandamide metabolism
Subtilisin/Kex2p-like proprotein convertase inhibitor
Broad spectrum, irreversible inhibitor of serine proteases
Potent renin inhibitor; antihypertensive
Neutral endopeptidase and endothelin converting enzyme inhibitor
Potent thrombin inhibitor
Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin
Endothelin-converting enzyme (ECE) inhibitor
Highly potent and selective renin inhibitor
Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Insulin degrading enzyme (IDE) inhibitor
High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant
Potent and selective β-secretase (BACE) inhibitor
Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B