Pepstatin A
Purity: ≥95%
Biological Activity
Pepstatin A is an irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).Technical Data
(Modifications: Val-1 = N-terminal iso-Valeryl, X-3 = X-5 = Sta)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-?1
P Tripathi, N Rodriguez-, JR Klim, AS de Boer, S Agrawal, J Sandoe, CS Lopes, KS Ogliari, LA Williams, M Shear, LL Rubin, K Eggan, Q Zhou
Stem Cell Reports, 2017;0(0):. -
An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells
A Sasahara, K Tominaga, T Nishimura, M Yano, E Kiyokawa, M Noguchi, M Noguchi, H Kanauchi, T Ogawa, H Minato, K Tada, Y Seto, A Tojo, N Gotoh
Oncotarget, 2017;8(15):24869-24881. -
Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation.
Sato et al.
Cancer Res., 2007;67:9677 -
Mode of inhibition of acid proteases by pepstatin.
Marciniszyn et al.
J.Biol.Chem., 1976;251:7088
Product Datasheets
Citations for Pepstatin A
The citations listed below are publications that use Tocris products. Selected citations for Pepstatin A include:
3 Citations: Showing 1 - 3
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Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation.
Authors: Berg Et al.
Cell Rep 2019;27:2837
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Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.
Authors: Guerroue Et al.
Mol Cell 2017;68:786
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WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma.
Authors: Tsai Et al.
J Neurosci 2013;4:e792
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Used to make up a lysis buffer for an ELISA (DYC1047-2), worked well.
use this as a protease inhibitor in my protein isolation buffer. It was a beneficial product for the Rat profiling cytokine assay kit.
