E 64d

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer.
   Kim et al.
   Autophagy, 2008;4:659
2. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation.
   Sato et al.
   Cancer Res., 2007;67:9677
3. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy.
   Tanada et al.
   Autophagy, 2005;1:84
4. Inhibition of cysteine proteinases in lysosomes and whole cells.
   Wilcox and Mason
   Biochem.J., 1992;285:495
5. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor.
   Hoffmann et al.
   Cell, 2020;

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