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SSM 3 trifluoroacetate

Catalog #: 5253
4 Citations Datasheet
Catalog # Availability Size / Price Qty
5253/10
SSM 3 trifluoroacetate | CAS No. 2320930-10-5 | Furin Inhibitors
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Description: Potent furin inhibitor

Chemical Name: rel-N,N''-[[(1R,3S,4S,6R)-4,6-Bis[(aminoiminomethyl)amino]-1,3-cyclohexanedyil]bis(oxy-4,1-phenylene)]bisguanidine tetratrifluoroacetate salt

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SSM 3 trifluoroacetate is a potent furin inhibitor (EC50 = 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.

Technical Data

M.Wt:
952.66
Formula:
C22H32N12O2.4CF3CO2H
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2320930-10-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.
    Remacle
    Int.J.Biochem.Cell Biol., 2010;42:987

Product Datasheets

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Citations for SSM 3 trifluoroacetate

The citations listed below are publications that use Tocris products. Selected citations for SSM 3 trifluoroacetate include:

4 Citations: Showing 1 - 4

  1. The subtilisin-like protease furin regulates hemin-induced CD63 surface expression on platelets.
    Authors: Dicenta Et al.
    Biochem.Biophys.Res.Commun.  2024;701:149629
  2. An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cell.
    Authors: Hervouet Et al.
    PLoS Pathog.  2022;18:e1010798
  3. Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.
    Authors: Rui Et al.
    J Clin Invest  2021;131
  4. Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
    Authors: Cheng Et al.
    Cell Rep.  2020;33

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