Leupeptin hemisulfate
Purity: ≥95%
Biological Activity
Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.Technical Data
(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
- This peptide is supplied in gross weight.
Background References
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An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells
A Sasahara, K Tominaga, T Nishimura, M Yano, E Kiyokawa, M Noguchi, M Noguchi, H Kanauchi, T Ogawa, H Minato, K Tada, Y Seto, A Tojo, N Gotoh
Oncotarget, 2017;8(15):24869-24881. -
LOXL2 status correlates with tumor stage and regulates integrin levels to promote tumor progression in ccRCC.
Hase H, Jingushi K, Ueda Y, Kitae K, Egawa H, Ohshio I, Kawakami R, Kashiwagi Y, Tsukada Y, Kobayashi T, Nakata W, Fujita K, Uemura M, Nonomura N, Tsujikawa K
Mol Cancer Res, 2014;12(12):1807-17. -
Cell-penetrating inhibitors of calpain.
Mehdi
TiBS, 1991;16:150 -
Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.
Sarin et al.
J.Immunol., 1994;153:862 -
Developing selective inhibitors of calpain.
Wang
TiPS, 1990;11:139
Product Datasheets
Citations for Leupeptin hemisulfate
The citations listed below are publications that use Tocris products. Selected citations for Leupeptin hemisulfate include:
2 Citations: Showing 1 - 2
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Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation.
Authors: Berg Et al.
Cell Rep 2019;27:2837
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Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity.
Authors: Haller Et al.
J Pharmacol Exp Ther 2015;10:2269
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I have used this product as the protease inhibitor in my protein isolation cocktail mix.
We used Leupeptin hemisulfate as a protease inhibitor to restore surface antigen in cell suspension cultures. We've used it both in vitro and in vivo.
