6bK
Chemical Name: (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide
Purity: ≥95%
Biological Activity
6bK is an insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.This compound is supplied in net weight as the TFA salt.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
- This compound is supplied in net weight as the TFA salt.
Background References
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Anti-diabetic activity of Ins-degrading enzyme inhibitors mediated by multiple hormones.
Maianti et al.
Nature, 2014;511:94
Product Datasheets
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