PMSF

Catalog #: 4486
3 Citations Datasheet

Catalog #	Availability	Size / Price	Qty
4486/50

PMSF | CAS No. 329-98-6 | Additional Synthetic Protease Inhibitors

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Description: Non-selective protease inhibitor; also blocks anandamide metabolism

Chemical Name: Phenylmethylsulfonyl fluoride

Purity: ≥98%

View All Products for Additional Synthetic Protease Inhibitors

Product Details

Citations (3)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PMSF is a non-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamide (Cat. No. 1339) in a rodent model of cannabimimetic activity. Unstable in water (t_1/2 ~ 60 mins at pH 7.5). Brain penetrant.

Technical Data

M.Wt:

174.19

Formula:

C₇H₇FO₂S

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

329-98-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase, chymotrypsin and trypsin.
Turini et al.
J.Pharmacol.Exp.Ther., 1969;167:98
The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity.
Compton & Martin
J.Pharmacol.Exp.Ther., 1997;283:1138
Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide.
Day et al.
Mol.Pharmacol., 2001;59:1369

Product Datasheets

COA view current batch

SDS

Citations for PMSF

The citations listed below are publications that use Tocris products. Selected citations for PMSF include:

3 Citations: Showing 1 - 3

Structural basis of selective cannabinoid CB2 receptor activation.
Authors: Partha Et al.
Nat Commun 2023;14:1447
A simple protocol to produce mature human-induced pluripotent stem cell-derived cardiomyocytes.
Authors: Yingqiong Et al.
STAR Protoc 2021;2:100912
Rapid assessment of DCLK1 inhibitors using a peptide substrate mobility shift assay.
Authors: Yan Et al.
STAR Protoc 2021;2:100587

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