Aprotinin
Biological Activity
Aprotinin is a competitive serine protease inhibitor. Reversibly binds to and blocks the enzymatic active site. Inhibits a range of serine proteases including trypsin, chymotrypsin, kallikrein and plasmin. Inhibits cytopathogenic effect of SARS-CoV-2 and double-stranded RNA formation in SARS-CoV-2-infected cells.This product is from Bovine Lung.
Technical Data
(Modifications: Disulfide bridges: 5-55, 14-38, 30-51)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
- from Bovine Lung
Background References
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Elastase and tryptase govern TNFa-mediated production of active chemerin by adipocytes.
Parlee et al.
PLoS ONE, 2012;7:e51072 -
Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.
Reichel et al.
PLoS ONE, 2011;6:e17229 -
SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles.
Bojkova et al.
BioRxiv - Paper not yet peer reviewed., 2020; -
bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice
L Parma, HAB Peters, TJ Sluiter, KH Simons, P Lazzari, MR de Vries, PHA Quax
Sci Rep, 2020;10(1):15968.
Product Datasheets
Citations for Aprotinin
The citations listed below are publications that use Tocris products. Selected citations for Aprotinin include:
4 Citations: Showing 1 - 4
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Induction of Apoptosis and Decrease of Autophagy in Colon Cancer Cells by an Extract of Lyophilized Mango Pulp.
Authors: María Elena Et al.
Int J Environ Res Public Health 2023;20
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Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness.
Authors: Yan Et al.
Cell Metab 2022;34:90-105.e7
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Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation.
Authors: Berg Et al.
Cell Rep 2019;27:2837
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Poly(ethylene glycol)-crosslinked gelatin hydrogel substrates with conjugated bioactive peptides influence endothelial cell behavior.
Authors: Simon C Et al.
Biomaterials 2019;201:99-112
FAQs
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Average Rating: 4.5 (Based on 2 Reviews)
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Used to make a buffer for an ELISA kit (DYC1047-2). Worked well.
Used in surgery research. Reduces inflammation and bleeding. Reasonably priced. You can dilute this aprotinin depending on your intended use, though dilute solutions are typically less stable. Will definitely purchase from R&D again.
