Pep 2-8
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Description: Potent PCSK9 inhibitor
Purity: ≥95%
Biological Activity
Pep 2-8 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.Technical Data
M.Wt:
1715.88
Formula:
C83H110N16O24
Sequence:
TVFTSWEEYLDWV
(Modifications: Thr-1 = N-terminal Ac, Val-13 = C-terminal amide)
Solubility:
Soluble to 2 mg/ml in PBS (pH 7.4)
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1541011-97-5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor.
Zhang et al.
J.Biol.Chem., 2014;289:942
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