AEBSF
Chemical Name: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Purity: ≥98%
Biological Activity
AEBSF is a broad spectrum, irreversible inhibitor of serine proteases. Also inhibits NADPH oxidase activation in vitro. Attenuates airway inflammation in a mouse model of airway allergy.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth.
Birukawa N, Murase K, Sato Y, Kosaka A, Yoneda A, Nishita H, Fujita R, Nishimura M, Ninomiya T, Kajiwara K, Miyazaki M, Nakashima Y, Ota S, Murakami Y, Tanaka Y, Minomi K, Tamura Y, Niitsu Y
J Biol Chem, 2014;289(29):20209-21. -
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds.
Diatchuk et al.
J.Biol.Chem., 1997;272:13292 -
Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease.
Saw et al.
PLoS ONE, 2012;7:e41107
Product Datasheets
Citation for AEBSF
The citations listed below are publications that use Tocris products. Selected citations for AEBSF include:
1 Citation: Showing 1 - 1
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Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects.
Authors: Xianglan Et al.
J Allergy Clin Immunol 2019;144:426-441.e3
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