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Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
SB 431542 synthesized to cGMP guidelines
Highly selective GSK-3 inhibitor; acts as Wnt activator
EZH2 histone methyltransferase inhibitor
CHIR 99021 synthesized to cGMP guidelines
Selective inhibitor of TGF-βRI, ALK4 and ALK7
PORCN inhibitor; inhibits Wnt processing and secretion
Potent tankyrase inhibitor
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
Potent and selective inhibitor of TGF-βRI
Potent inhibitor of MEK1/2
Enhances the generation of iPSCs; increases reprogramming efficiency
Wnt/β-catenin signaling inhibitor; axin stabilizer
ROCK inhibitor; improves the efficiency of fibroblast reprogramming and induction of iPSCs
Inhibitor of Hedgehog (Hh) signaling
Histone deacetylase inhibitor
p53 inhibitor. Also aryl hydrocarbon receptor agonist
XAV 939 synthesized to cGMP guidelines
Retinoic acid analog; RAR agonist
Potent histone deacetylase inhibitor
Potent inhibitor of Wnt/β-catenin signaling
Histone deacetylase inhibitor
Irreversible inhibitor of LSD1; also inhibits MAO
Induces definitive endoderm formation in mouse and human ESCs
Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
Media supplement to boost cell growth; used as component of CEPT cocktail to enhance stem cell viability
RepSox synthesized to Ancillary Material Grade
Non-nucleoside DNA methyltransferase inhibitor
Potent, selective Rho-kinase (ROCK) inhibitor
DNA methyltransferase inhibitor
A 83-01 synthesized to Ancillary Material Grade
GSK-3β inhibitor; also inhibits cdks
Inhibitor of p53-mitochondrial binding
ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
Oct3/4 inducer; induces expression of pluripotent-associated genes
T3 synthesized to Ancillary Material Grade
Cell culture supplement for improving stem cell survival
Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO
endo-IWR 1 synthesized to Ancillary Material Grade
L-Ascorbic acid synthesized to Ancillary Material Grade