5-Azacytidine

Catalog #: 3842
6 Citations Datasheet

Catalog #	Availability	Size / Price	Qty
3842/50

5-Azacytidine | CAS No. 320-67-2 | Methyltransferase Inhibitors

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Description: DNA methyltransferase inhibitor

Chemical Name: 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Purity: ≥98%

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Product Details

Citations (6)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

5-Azacytidine is a DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.

Technical Data

M.Wt:

244.2

Formula:

C₈H₁₂N₄O₅

Solubility:

Soluble to 50 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

320-67-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

5-aza-Cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.
Schneider-Stock et al.
J.Pharmacol.Exp.Ther., 2005;312:525
Dissecting direct reprogramming through integrative genomic analysis.
Mikkelsen et al.
Nature, 2008;454:49
5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase.
Qian et al.
Stem Cells Dev., 2012;21:67

Product Datasheets

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SDS

⚠ WARNING: This product can expose you to chemicals including Azacitidine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Citations for 5-Azacytidine

The citations listed below are publications that use Tocris products. Selected citations for 5-Azacytidine include:

6 Citations: Showing 1 - 6

TET1 regulates fibroblast growth factor 8 transcription in Gn releasing hormone neurons.
Authors: Linscott and Chung
PLoS One 2019;14:e0220530
Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth.
Authors: Donald J Et al.
Oncotarget 2017;8:44159-44170
PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
Authors: Chandrakanthan Et al.
Proc Natl Acad Sci U S A 2016;113:E2306
5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
Authors: Bhuvanagiri Et al.
EMBO Mol Med 2014;6:1593
Progenitor cells identified by PDGFR-α expression in the developing and diseased human heart.
Authors: Chong Et al.
Cell Res 2013;22:1932
Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.
Authors: Perera Et al.
PLoS One 2009;4:e4488

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