RepSox

Biological Activity

RepSox synthesized to Ancillary Material Grade also available.

For more information about how RepSox may be used, see our protocols: Highly Efficient Generation of CiPSCs from MEFs, Generation of β cells from hPSCs, Reprogramming MEFs into Skeletal Muscle Progenitors.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
   KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
   Nat Commun, 2017;8(1):331.
2. The metalloprotease ADAM12 regulates the effector function of human Th17 cells.
   Zhou A, El Hed A, Mercer F, Kozhaya L, Unutmaz D
   PLoS ONE, 2013;8(11):e81146.
3. GARP-TGF-beta complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
   Zhou A, Kozhaya L, Fujii H, Unutmaz D
   J Immunol, 2013;190(10):5057-64.
4. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-γ type I receptor inhibitors.
   Gellibert et al.
   J.Med.Chem., 2004;47:4494
5. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.
   Li et al.
   Cell Stem Cell, 2009;4:16
6. A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog.
   Ichida et al.
   Cell Stem Cell, 2009;5:491
7. Stem-Cell-Derived beta-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity
   TM Triolo, JQ Matuschek, R Castro-Gut, AH Shilleh, SPM Williams, MS Hansen, K McDaniel, JM Barra, A Michels, HA Russ
   Cells, 2022;11(23):.

Product Datasheets