Thiazovivin
1 Image
Description: ROCK inhibitor; improves the efficiency of fibroblast reprogramming and induction of iPSCs
Chemical Name: N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide
Purity: ≥98%
Biological Activity
Thiazovivin is a selective, cell-permeable Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (IC50 = 0.5 μM). Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Thiazovivin improves the survival of human embryonic stem cells (hESCs) upon trypsinization and increases cell adhesion through the regulation of E-cadherin and significantly improves direct reprogramming efficiency. In combination with Valproic acid, sodium salt (Cat. No. 2815), Purmorphamine (Cat. No. 4551) and A 83-01 (Cat. No. 2939), Thiazovivin can be used to directly reprogram mouse embryonic fibroblasts into chemically induced neural stem cells.Technical Data
M.Wt:
311.36
Formula:
C15H13N5OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1226056-71-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Asymmetric bidirectional transcription from the FSHD-causing D4Z4 array modulates DUX4 production.
Block GJ, Petek LM, Narayanan D
PLoS ONE, 2012;7(4):e35532. -
Identification of direct negative crosstalk between the SLIT2 and Bone Morphogenetic Protein-Gremlin signaling pathways
KE Tumelty, N Higginson-, X Fan, P Bajaj, KM Knowlton, M Shamashkin, AJ Coyle, W Lu, SP Berasi
J. Biol. Chem., 2018;0(0):. -
Increased susceptibility to a? toxicity in neuronal cultures derived from familial Azheimer's disease (PSEN1-A246E) induced pluripotent stem cells
Enrique Armijo
Neurosci. Lett, 2016;0(0):. -
A chemical platform for improved induction of human iPSCs.
Lin et al.
Nat.Methods., 2009;6:805 -
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules.
Xu et al.
Proc.Natl.Acad.Sci.USA, 2010;107:8129
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Citations for Thiazovivin
The citations listed below are publications that use Tocris products. Selected citations for Thiazovivin include:
16 Citations: Showing 1 - 10
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Step-by-step protocols for non-viral derivation of transgene-free induced pluripotent stem cells from somatic fibroblasts of multiple mammalian species.
Authors: Toshiaki Et al.
Dev Growth Differ 2022;64:325-341
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Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency.
Authors: Jia-Jie Et al.
Cell Rep 2022;40:111240
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Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells.
Authors: Mansa Et al.
Cell Stem Cell 2022;29:36-51.e6
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Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems.
Authors: Lu Et al.
Nat Protoc 2022;17:2699-2719
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Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Authors: Kirsten Et al.
Sci Adv 2021;7
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Patch-clamp and multi-electrode array electrophysiological analysis in acute mouse brain slices.
Authors: Douglas G Et al.
STAR Protoc 2021;2:100442
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Clostridioides difficile-Associated Antibiotics Alter Human Mucosal Barrier Functions by Microbiome-Independent Mechanisms.
Authors: Douglas A Et al.
Antimicrob Agents Chemother 2020;64
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Xeno-Free Reprogramming of Peripheral Blood Mononuclear Erythroblasts on Laminin-521.
Authors: Yang Et al.
Curr Protoc Stem Cell Biol 2020;52:e103
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Spatially controlled stem cell differentiation via morphogen gradients: A comparison of static and dynamic microfluidic platforms.
Authors: Alexander R Et al.
J Vac Sci Technol A 2020;38:033205
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Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins.
Authors: Mayana Et al.
PLoS Negl Trop Dis 2020;14:e0008424
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Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids.
Authors: Omer Et al.
Cell Syst 2020;10:223-239.e9
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Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
Authors: Caires-J?nior
Nat Commun 2018;9(1):475
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Derivation and characterization of the NIH registry human stem cell line NYSCF101 under defined feeder-free conditions.
Authors: Sevilla Et al.
Stem Cell Res 2018;29:197
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Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways.
Authors: Tumelty Et al.
J Biol Chem 2018;293:3039
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Live imaging reveals that the first division of differentiating human embryonic stem cells often yields asymmetric fates.
Authors: Brown
Cell Rep 2017;21(2):301
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Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in na�ve human embryonic stem cells.
Authors: Xu Et al.
Proc Natl Acad Sci U S A 2016;113:E6382
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