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L-Ascorbic acid

Catalog #: 4055
16 Citations Datasheet
Catalog # Availability Size / Price Qty
4055/50
L-Ascorbic acid | CAS No. 50-81-7 | Compounds for Induced Pluripotent Stem Cells
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Description: Enhances the generation of iPSCs; increases reprogramming efficiency
Alternative Names: L-Ascorbate,Vitamin C

Chemical Name: 3-Oxo-L-gulofuranolactone

Purity: ≥99%

Product Details
Citations (16)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

L-Ascorbic acid is an inhibitor of Cav3.2 channels (IC50 = 6.5 μM); displays no effect on Cav3.1 or Cav3.3 channels heterologously expressed in HEK 293 cells. Also enhances the generation of induced pluripotent stem cells (iPSCs) from mouse and human somatic cells by increasing reprogramming efficiency. Commonly used antifade reagent in live cell microscopy. Naturally occurring antioxidant.

L-Ascorbic acid synthesized to Ancillary Material Grade also available.

For more information about how L-Ascorbic acid may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

Technical Data

M.Wt:
176.12
Formula:
C6H8O6
Solubility:
Soluble to 500 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
50-81-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The COPII cargo adapter SEC24C is essential for neuronal homeostasis
    B Wang, JH Joo, R Mount, BJW Teubner, A Krenzer, AL Ward, VP Ichhaporia, EJ Adams, R Khoriaty, ST Peters, SM Pruett-Mil, SS Zakharenko, D Ginsburg, M Kundu
    J. Clin. Invest., 2018;0(0):.
  2. Vitamin C as an antioxidant: evaluation of its role in disease prevention.
    Padayatty et al.
    J.Am.Coll.Nutr., 2003;22:18
  3. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.
    Nelson et al.
    J.Neurosci., 2007;27:12577
  4. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells.
    Esteban et al.
    Cell Stem Cell, 2010;6:71
  5. Mechanisms and advancement of antifading agents for fluorescence microscopy and single-molecule spectroscopy.
    Cordes et al.
    Phys.Chem.Chem.Phys., 2011;13:6699

Product Datasheets

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Citations for L-Ascorbic acid

The citations listed below are publications that use Tocris products. Selected citations for L-Ascorbic acid include:

16 Citations: Showing 1 - 10

  1. Evidence of shared transcriptomic dysregulation of HNRNPU-related disorder between human organoids and embryonic mice.
    Authors: Orly Et al.
    iScience  2023;26:105797
  2. High throughput 3D gel-based neural organotypic model for cellular assays using fluorescence biosensors.
    Authors: Molly E Et al.
    Commun Biol  2022;5:1236
  3. Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells.
    Authors: Richard Et al.
    Nat Genet  2022;54:1406-1416
  4. Generation of human elongating multi-lineage organized cardiac gastruloids.
    Authors: Janet L Et al.
    STAR Protoc  2022;3:101898
  5. The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling.
    Authors: Philippe Et al.
    iScience  2022;25:105066
  6. A combined human gastruloid model of cardiogenesis and neurogenesis.
    Authors: Janet L Et al.
    iScience  2022;25:104486
  7. Enhancement of Neuroglial Extracellular Matrix Formation and Physiological Activity of Dopaminergic Neural Cocultures by Macromolecular Crowding.
    Authors: Marc Et al.
    Cells  2022;11
  8. Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells.
    Authors: Tristan Et al.
    Stem Cell Rep.  2021;16:3076
  9. Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip.
    Authors: Qian Et al.
    Elife  2020;9
  10. Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.
    Authors: Jianhui Et al.
    Nat Commun  2020;11:550

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