QS 11
Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
Purity: ≥98%
Biological Activity
QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A chemical approach to stem cell biology
Emre et al.
Curr.Opin.Chem.Biol., 2007;11:252 -
Small-molecule synergist of the Wnt/β-catenin signaling pathway.
Zhang et al.
Proc.Natl.Acad.Sci.USA, 2007;104:7444
Product Datasheets
Citations for QS 11
The citations listed below are publications that use Tocris products. Selected citations for QS 11 include:
2 Citations: Showing 1 - 2
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Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression.
Authors: Gowda Et al.
Mol Cell Biol 2018;38
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Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles
Authors: Wu, J Et al.
Scientific Reports 2016;6:29418
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