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endo-IWR 1

Catalog #: 3532
26 Citations Datasheet
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3532/50
endo-IWR 1 | CAS No. 1127442-82-3 | beta-Catenin Compounds
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Description: Wnt/β-catenin signaling inhibitor; axin stabilizer

Chemical Name: rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide

Purity: ≥98%

Product Details
Citations (26)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

endo-IWR 1 is an inhibitor of Wnt signaling. Induces an increase in axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Promotes endothelial cell specification of cardiac progenitor cells and may be used in protocols for the generation of retinal pigment epithelial cells from hPSCs.

Negative Control also available.

endo-IWR 1 synthesized to Ancillary Material Grade also available.

For more information about how endo-IWR 1 may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).

Technical Data

M.Wt:
409.44
Formula:
C25H19N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1127442-82-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro.
    Gao W, Zhou P, Ma X, Tschudy-Seney B, Chen J, Magner N, Revzin A, Nolta J, Zern M, Duan Y
    PLoS ONE, 2014;9(11):e112698.
  2. Wnt/?-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells
    Y Kishimoto, B Ohkawara, T Sakai, M Ito, A Masuda, N Ishiguro, C Shukunami, D Docheva, K Ohno
    PLoS ONE, 2017;12(7):e0182051.
  3. Hepcidin regulation in prostate and its disruption in prostate cancer.
    Tesfay L, Clausen K, Kim J, Hegde P, Wang X, Miller L, Deng Z, Blanchette N, Arvedson T, Miranti C, Babitt J, Lin H, Peehl D, Torti F, Torti S
    Cancer Res, 2015;75(11):2254-63.
  4. WNT/beta-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets.
    Suzuki A, Pelikan R, Iwata J
    Mol Cell Biol, 2015;35(10):1763-76.
  5. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
    Chen et al.
    Nat.Chem.Biol., 2009;5:100
  6. Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
    Lu et al.
    Bioorg.Med.Chem.Lett., 2009;19:3825
  7. Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex.
    Kadoshima et al.
    Proc.Natl.Acad.Sci.USA., 2013;110:20284
  8. Generation of cerebral organoids from human pluripotent stem cells.
    Lancaster et al.
    Nat.Protoc., 2015;9:2329
  9. Wnt inhibition promotes vascular specification of embryonic cardiac progenitors.
    Reichman et al.
    Development, 2018;145:dev159905
  10. TAZ is required for lung alveolar epithelial cell differentiation after injury
    T Sun, Z Huang, H Zhang, C Posner, G Jia, TR Ramalingam, M Xu, HD Brightbill, JG Egen, A Dey, JR Arron
    JCI Insight, 2019;5(0):.

Product Datasheets

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Citations for endo-IWR 1

The citations listed below are publications that use Tocris products. Selected citations for endo-IWR 1 include:

26 Citations: Showing 1 - 10

  1. Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling.
    Authors: Erika Et al.
    Sci Rep  2023;13:3186
  2. DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.
    Authors: W Hayes Et al.
    JCI Insight  2022;7
  3. Suspension culture promotes serosal mesothelial development in human intestinal organoids.
    Authors: Capeling Et al.
    Cell Rep.  2022;38:110379
  4. Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
    Authors: Jia Et al.
    J Neurochem  2022;161:463-477
  5. Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human.
    Authors: Min Et al.
    Nat Commun  2022;13:3883
  6. A specialized bone marrow microenvironment for fetal haematopoiesis.
    Authors: Martin Et al.
    Nat Commun  2022;13:1327
  7. Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells.
    Authors: Timothy C Et al.
    Elife  2022;11
  8. An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates.
    Authors: Alexandre P Et al.
    Elife  2022;11
  9. Replating Protocol for Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    Authors: Esra Et al.
    Methods Mol Biol  2021;2520:161-170
  10. SEM/FIB Imaging for Studying Neural Interfaces.
    Authors: Amos Et al.
    Dev Neurobiol  2020;80:305-315
  11. Electrophysiologic Characterization of Developing Human Embryonic Stem Cell-Derived Photoreceptor Precursors.
    Authors: Alon Et al.
    Invest Ophthalmol Vis Sci  2020;61:44
  12. Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
    Authors: Geoffrey Et al.
    Cell Rep  2020;32:107922
  13. Vascularized human cortical organoids (vOrganoids) model cortical development in vivo.
    Authors: Le Et al.
    PLoS Biol  2020;18:e3000705
  14. TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease.
    Authors: Eunjeong Et al.
    Proc Natl Acad Sci U S A  2020;117:29001-29012
  15. Establishment of porcine and human expanded potential stem cells.
    Authors: Gao Et al.
    Nat Cell Bio  2019;21:687
  16. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
    Authors: Garcia Et al.
    Front Neurosci  2019;13:669
  17. The role of acetyltransferases for the temporal-specific accessibility of β-catenin to the myogenic gene locus.
    Authors: Suzuki Et al.
    Sci Rep  2018;8:15057
  18. hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate.
    Authors: Ali H Et al.
    Cell Stem Cell  2018;23:60-73.e6
  19. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles.
    Authors: Yamoah Et al.
    Int J Nanomedicine  2018;13:6073
  20. Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells.
    Authors: Kishimoto
    PLoS One  2017;12(7):e0182051
  21. Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
    Authors: Kennedy Et al.
    Proc Natl Acad Sci U S A  2016;113:3545
  22. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
    Authors: Latos Et al.
    Nat Commun  2015;6:7776
  23. Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron.
    Authors: Lindström Et al.
    Mol Cell Biol  2015;3:e04000
  24. WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets.
    Authors: Suzuki Et al.
    Development  2015;35:1763
  25. TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate.
    Authors: Iwata Et al.
    Nat Protoc  2014;141:909
  26. A conserved role for non-neural ectoderm cells in early neural development.
    Authors: Cajal Et al.
    Development  2014;141:4127

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