exo-IWR 1
Chemical Name: 4-[(3aR,4R,7S,7aS-rel)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Purity: ≥99%
Biological Activity
exo-IWR 1 is a negative control for endo-IWR 1 25-fold less active than endo-IWR 1; exhibits decreased activity against the Wnt/β-catenin pathway.Active Analog also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
Lu et al.
Bioorg.Med.Chem.Lett., 2009;19:3825 -
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
Chen et al.
Nature Chem.Biol., 2008;5:100 -
TAZ is required for lung alveolar epithelial cell differentiation after injury
T Sun, Z Huang, H Zhang, C Posner, G Jia, TR Ramalingam, M Xu, HD Brightbill, JG Egen, A Dey, JR Arron
JCI Insight, 2019;5(0):.
Product Datasheets
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