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Potent pro-apoptotic anticancer agent; activates caspase-3
Antitumor antibiotic agent. Inhibits DNA topoisomerase II
DNA cross-linking antitumor agent
DNA cross-linking antitumor agent
DNA-methylating antitumor agent
Alkylating agent; chemotherapeutic
DNA cross-linking antitumor agent
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
Purine analog; inhibits DNA synthesis
DNA alkylator; antitumor and induces diabetes
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
Suppressor of MDK expression; inhibits PI 3-K signaling
Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
Downregulates Bcl-2 and Mcl-1; pro-apoptotic
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
High affinity and selective activator of Bax
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
Hypoxia-activated DNA alkylating agent prodrug
Selectively induces cancer cell apoptosis
Potent fatty acid synthase inhibitor; proapoptotic
Cytostatic agent; exhibits DNA alkylating and purine analog properties
Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
Potent and selective HDAC8 inhibitor
Deoxyadenosine analog; pro-apoptotic
Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry
Pan-histone deacetylase inhibitor
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
Potent and selective MEK inhibitor; orally bioavailable
Potent UNC-51-like kinase 1 (ULK1) agonist
Potent pan-HDAC inhibitor