Carboplatin
Chemical Name: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
Purity: ≥99%
Biological Activity
Carboplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines
K Ishiguro, YL Zhu, ZP Lin, PG Penketh, K Shyam, R Zhu, RP Baumann, AC Sartorelli, TJ Rutherford, ES Ratner
J Transl Sci, 2016;2(2):117-124. -
Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited.
Natarajan et al.
Biochem.Pharmacol., 1999;58:1625 -
Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks.
Yang et al.
Radiation Res., 1995;143:302 -
High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisp. but not carbop. ototoxicity.
Thomas et al.
Mol.Pharmacol., 2006;70:23
Product Datasheets
Citations for Carboplatin
The citations listed below are publications that use Tocris products. Selected citations for Carboplatin include:
3 Citations: Showing 1 - 3
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Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines.
Authors: Ishiguro Et al.
J Transl Sci 2016;2:117
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Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC.
Authors: Massey
PLoS One 2015;10:e0134306
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Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.
Authors: Bryant Et al.
Cell Death Differ 2014;14:570
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