Temozolomide
Chemical Name: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
Purity: ≥99%
Biological Activity
Temozolomide is a DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC50 = 5.0 μM for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC (Cat No. 5029).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro.
Dittmann LM, Danner A, Gronych J, Wolter M, Stuhler K, Grzendowski M, Becker N, Bageritz J, Goidts V, Toedt G, Felsberg J, Sabel MC, Barbus S, Reifenberger G, Lichter P, Tews B
Oncogene, 2012;31(29):3409-18. -
Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death.
Cheng Y, Sk UH, Zhang Y
PLoS ONE, 2012;7(4):e35104. -
IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
Matthew N Svalina
Sci Rep, 2016;6(0):27012. -
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells.
Kanzawa et al.
Cell Death Differ., 2004;11:448 -
Preclinical antitumor activity of temozol. in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Plowman et al.
Cancer Res., 1994;54:3793 -
Antitumor imidazotetraazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozol.
Clark et al.
J.Med.Chem., 1995;38:1493
Product Datasheets
Citations for Temozolomide
The citations listed below are publications that use Tocris products. Selected citations for Temozolomide include:
6 Citations: Showing 1 - 6
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Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture.
Authors: Deng Et al.
J Pharmacol Exp Ther 2017;360:215
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Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer.
Authors: Canello Et al.
PLoS One 2014;9:e113854
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BET bromodomain proteins are required for glioblastoma cell proliferation.
Authors: Pastori Et al.
Epigenetics 2014;9:611
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Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.
Authors: Prabhu Et al.
PLoS One 2013;7:e52265
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The DNA repair protein ALKBH2 mediates temozol. resistance in human glioblastoma cells.
Authors: Johannessen Et al.
Neuro Oncol 2013;15:269
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Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.
Authors: Hu Et al.
Cancer Res 2012;72:3873
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