Betulinic acid
Chemical Name: (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid
Biological Activity
Betulinic acid is a natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC50 = 1.04 μM, efficacy 83%). Betulinic acid suppresses areobic glycolysis by regulating the Cav-1/NF-κB/c-Myc pathway in and inhibits growth in breast cancer cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids
KC Murphy, J Whitehead, PC Falahee, D Zhou, SI Simon, JK Leach
Stem Cells, 2017;0(0):. -
CXCR4 signaling in macrophages contributes to periodontal mechanical hypersensitivity in Porphyromonas gingivalis-induced periodontitis in mice
H Nagashima, M Shinoda, K Honda, N Kamio, M Watanabe, T Suzuki, N Sugano, S Sato, K Iwata
Mol Pain, 2017;13(0):1744806916689. -
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
Genet et al.
J.Med.Chem., 2010;53:178 -
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.
Kashiwada et al.
J.Med.Chem., 1996;39:1016 -
Betulinic acid for cancer treatment and prevention.
Fulda
Int.J.Mol.Sci., 2008;9:1096
Product Datasheets
Citations for Betulinic acid
The citations listed below are publications that use Tocris products. Selected citations for Betulinic acid include:
2 Citations: Showing 1 - 2
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MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization.
Authors: Qing Et al.
Sci Rep 2022;12:4183
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Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum.
Authors: Inoue Et al.
Neurotox Res 2012;303:G810
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