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Cyclophosphamide

Catalog #: 4091 Datasheet
Catalog # Availability Size / Price Qty
4091/50
Cyclophosphamide | CAS No. 50-18-0 | Apoptosis Inducer Compounds
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Description: Alkylating agent; chemotherapeutic

Chemical Name: 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

Purity: ≥99%

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Biological Activity

Cyclophosphamide is a nitrogen mustard alkylating agent and prodrug. Phosphoramide mustard (active metabolite) forms DNA cross-links leading to cell death. Inhibits aldehyde dehydrogenase 1 (ALDH1) through its degradation product acrolein. Chemotherapeutic for the treatment of breast cancer; regulates Bax and Bcl-2 expression when administered with etoposide (Cat. No. 1226) in breast cancer cell lines.

Technical Data

M.Wt:
261.09
Formula:
C7H15Cl2N2O2P
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
50-18-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. DNA strand breaks and DNA cross-links in peripheral mononuclear blood cells of ovarian cancer patients during chemotherapy with cyclophosphamide/carboplatin.
    Hengstler et al.
    Cancer Res., 1992;15:52
  2. Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein.
    Ren et al.
    Drug Metab.Disp., 1999;27:133
  3. Regulation of BAX and BCL-2 expression in breast cancer cells by chemotherapy.
    Gibson et al.
    Breast Cancer Research and Treatment, 1999;55:107

Product Datasheets

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SDS
⚠ WARNING: This product can expose you to chemicals including Cyclophosphamide (anhydrous), which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

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