Etoposide

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Toposiomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes.
   Burden et al.
   J.Biol.Chem., 1996;271:29238
3. Etoposide: four decades of development of a topoisomerase II inhibitor.
   Hande et al.
   Eur.J.Cancer, 1998;34:1514
4. Antitumor agents.3.Synthesis and biological activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.
   Terada et al.
   J.Med.Chem., 1993;36:1689
5. Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens.
   Nicolson et al.
   J.Virol., 2016;90:7019

Product Datasheets