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Mitomycin C

Catalog #: 3258
5 Citations Datasheet
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Mitomycin C | CAS No. 50-07-7 | Apoptosis Inducer Compounds
1 Image
Description: DNA cross-linking antitumor agent
Alternative Names: Ametycine

Chemical Name: [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Mitomycin C is an antibiotic and antitumor agent. Covalently binds DNA forming intra- and interstrand crosslinks. Inhibits DNA synthesis. Also used for MEF/STO feeder layer preparation in stem cell culture.

Technical Data

M.Wt:
334.33
Formula:
C15H18N4O5
Solubility:
Soluble to 1 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
50-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. VSIG-3 as a ligand of VISTA inhibits human T-cell function.
    Wang J, Wu G, Manick B, Hernandez V, Renelt M, Erickson C, Guan J, Singh R, Rollins S, Solorz A, Bi M, Li J, Grabowski D, Dirkx J, Tracy C, Stuart T, Ellinghuysen C, Desmond D, Foster C, Kalabokis V
    Immunology, 0;156(1):74-85.
  2. Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C.
    Kim KK, Lange TS, Singh RK
    BMC Cancer, 2012;12(0):147.
  3. Derivation of mouse embryonic stem cells.
    Bryja et al.
    Nat.Protoc., 2006;1:2082
  4. Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9.
    Park et al.
    Nat.Protoc., 2016;11:2154
  5. Isolation and structure of a covalent cross-link adduct between mito. C and DNA.
    Tomasz et al.
    Science, 1987;235:1204
  6. Isolation and structure of an intrastrand cross-link adduct of mito. C and DNA.
    Bizanek et al.
    Biochemistry, 1992;31:3084
  7. HER2-intronic miR-4728-5p facilitates HER2 expression and accelerates cell proliferation and migration by targeting EBP1 in breast cancer
    Y Zhou, Y Yuan, L Li, X Wang, Y Quan, C Liu, M Yu, X Hu, X Meng, Z Zhou, CY Zhang, X Chen, M Liu, C Wang
    PLoS ONE, 2021;16(2):e0245832.

Product Datasheets

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SDS
⚠ WARNING: This product can expose you to chemicals including Mitomycin C, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Citations for Mitomycin C

The citations listed below are publications that use Tocris products. Selected citations for Mitomycin C include:

5 Citations: Showing 1 - 5

  1. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain DA neurons.
    Authors: Kishinevsky Et al.
    Nat Commun  2018;9:4345
  2. Molecular basis of MMC enhanced corneal sensory nerve repair after debridement wounding.
    Authors: Stepp Et al.
    Sci Rep  2018;8:16960
  3. Elucidating Compound Mechanism of Action by Network Perturbation Analysis.
    Authors: Woo Et al.
    Cell  2015;162:441
  4. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
    Authors: Reinhardt Et al.
    PLoS One  2013;8:e59252
  5. Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton.
    Authors: Mayanagi Et al.
    J Biol Chem  2008;283:31183

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