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Fludarabine

Catalog #: 3495
10 Citations Datasheet
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3495/50
Fludarabine | CAS No. 21679-14-1 | DNA, RNA and Protein Synthesis Inhibitors
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Description: Purine analog; inhibits DNA synthesis

Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine

Purity: ≥98%

Product Details
Citations (10)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Fludarabine is a purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.

Technical Data

M.Wt:
285.23
Formula:
C10H12FN5O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
21679-14-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Robinson T, Liu J, Vizeacoumar F, Sun T, Maclean N, Egan S, Schimmer A, Datti A, Zacksenhaus E
    PLoS ONE, 2013;8(11):e78641.
  2. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling.
    Frank et al.
    Nat.Med., 1999;5:444
  3. Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation.
    Torella et al.
    Am.J.Physiol.Heart Circ.Physiol., 2007;292:H2935
  4. In vitro evaluation of fludar. in combination with cyclophosph. and/or mitoxan. in B-cell chronic lymphocytic leukemia.
    Bellosillo et al.
    Blood, 1999;94:2836
  5. Antitumor activity of fludar. against human multiple myeloma in vitro and in vivo.
    Meng et al.
    Eur.J.Haematol., 2007;79:486
  6. Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis
    A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani, Y Norimatsu, M Fukayama, S Ebata, T Fukasawa, A Yoshizaki-, Y Asano, K Morikawa, Y Kazoe, K Mawatari, T Kitamori, S Sato
    Nature Communications, 2021;12(1):5947.

Product Datasheets

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Citations for Fludarabine

The citations listed below are publications that use Tocris products. Selected citations for Fludarabine include:

10 Citations: Showing 1 - 10

  1. Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice.
    Authors: Yuwei Et al.
    Nat Commun  2023;14:1806
  2. Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases.
    Authors: Alexey Et al.
    EMBO J  2022;41:e111608
  3. A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression.
    Authors: Xiang Et al.
    J Exp Clin Cancer Res  2022;41:174
  4. Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics.
    Authors: Brij B Et al.
    iScience  2021;24:103339
  5. STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina.
    Authors: Fred Et al.
    Cell Rep  2020;30:2195-2208.e5
  6. Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin.
    Authors: Beate Et al.
    Cell Mol Immunol  2020;17:380-394
  7. E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis.
    Authors: Haiyan Et al.
    Aging (Albany NY)  2019;11:3536-3550
  8. Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.
    Authors: Nathalie Et al.
    PLoS One  2014;9:e99211
  9. Diverse intracellular pathogens activate type III IF. expression from peroxisomes.
    Authors: Odendall Et al.
    Nat Immunol  2014;15:717
  10. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One  2013;8:e78641

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