Cladribine
Chemical Name: (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol
Purity: ≥99%
Biological Activity
Cladribine is an adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC50 = 0.11 - 0.28 μM). Displays activity in vitro and in vivo. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.
Seto et al.
J. Clin. Invest., 1985;75:377 -
Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies.
Bryson et al.
Drugs, 1993;46:872 -
Older and new formulations of cladr. Pharmacology and clinical efficacy in hematological malignancies.
Robak et al.
Recent Pat. Anticancer Drug Discov., 2006;1:23
Product Datasheets
Citation for Cladribine
The citations listed below are publications that use Tocris products. Selected citations for Cladribine include:
1 Citation: Showing 1 - 1
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Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium.
Authors: Weiterer Et al.
J Biomed Sci 2015;10:e0143163
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