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γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
Potent and selective γ-secretase inhibitor
Inhibitor of JNK signaling
β-secretase (BACE) inhibitor; inhibits amyloid assembly
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
Inhibitor of Aβ42 fibril formation
Selective inhibitor of PKCβII
Potent γ-secretase inhibitor
γ-secretase inhibitor; attenuates amyloid plaque deposition
Potent γ-secretase inhibitor
Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo