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MRK 560

Catalog #: 4000
3 Citations Datasheet
Catalog # Availability Size / Price Qty
4000/10
4000/50
MRK 560 | CAS No. 677772-84-8 | Secretase Inhibitors
1 Image
Description: γ-secretase inhibitor; attenuates amyloid plaque deposition

Chemical Name: N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

MRK 560 is a γ-secretase inhibitor, which selectively inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. MRK 560 reduces levels of Aβ in vitro (inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with an IC50 of 0.65 nM) and attenuates plaque deposition. This compound is orally bioavailable.

Extrernal Portal Information

The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MRK 560 is reviewed.

Technical Data

M.Wt:
517.92
Formula:
C19H17ClF5NO4S2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
677772-84-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans).

Product Datasheets

Citations for MRK 560

The citations listed below are publications that use Tocris products. Selected citations for MRK 560 include:

3 Citations: Showing 1 - 3

  1. Development of a central nervous system axonal myelination assay for high throughput screening.
    Authors: Lariosa-Willingham Et al.
    BMC Neurosci  2016;17:16
  2. Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aβ-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aβ agents.
    Authors: Qi Et al.
    Acta Neuropathol Commun  2014;2:175
  3. GSI promotes vincristine-induced apoptosis by enhancing multi-polar spindle formation.
    Authors: Singh Et al.
    Cell Cycle  2014;13:157

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