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PF 3084014 hydrobromide

Catalog #: 5751 Datasheet
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5751/10
PF 3084014 hydrobromide | CAS No. 1962925-29-6 | gamma-Secretase
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Description: Potent γ-secretase inhibitor

Chemical Name: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide

Purity: ≥98%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PF 3084014 hydrobromide is a potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

Technical Data

M.Wt:
651.47
Formula:
C27H41F2N5O.HBr
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1962925-29-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.
    Lanz et al.
    J.Pharmacol.Exp.Ther., 2010;334:269

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