Davunetide

Biological Activity

Davunetide is a highly potent active component of activity-dependent neuroprotective protein (ADNP). Prevents β-amyloid aggregation. Reduces hyperphosphorylated tau levels and increases tau-microtubule interactions; neuroprotective at femtomolar concentrations in vitro. Exerts neuroprotective effects in schizophrenia models associated with microtubule-autophagy insufficiency in MAP6-deficient mice. Modulates HIFs and VEGF expression and suppresses retinal cell apoptosis in an in vivo diabetic retinopathy model.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze
   Gozes et al.
   J.Pharmacol.Exp.Ther., 2000;293:1091
2. ADNP/NAP dramatically increase microtubule end-binding protein-Tau interaction: a novel avenue for protection against tauopathy.
   Ivashko-Pachima et al.
   Mol Psychiatry, 2017;22:1335
3. ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease.
   Sragovich et al.
   Bioessays, 2017;39:doi: 10.1002
4. Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide.
   Bassan et al.
   J.Neurochem., 1999;72:1283
5. Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease.
   Melo et al.
   Exp.Brain Res., 2017;235:731
6. NAP counteracts hyperglycemia/hypoxia induced retinal pigment epithelial barrier breakdown through modulation of HIFs and VEGF expression.
   D'Amico et al.
   J.Cell Physiol., 2018;233:1120

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