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EGCG

Catalog #: 4524
11 Citations Datasheet
Catalog # Availability Size / Price Qty
4524/50
EGCG | CAS No. 989-51-5 | Amyloid beta Peptide Inhibitors
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Description: β-secretase (BACE) inhibitor; inhibits amyloid assembly
Alternative Names: Epigallocatechin gallate

Chemical Name: 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

Purity: ≥98%

Product Details
Citations (11)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

EGCG is a β-secretase (BACE1) inhibitor (IC50 = 1.6 μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate dehydrogenase. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.

Technical Data

M.Wt:
458.37
Formula:
C22H18O11
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
989-51-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for EGCG

The citations listed below are publications that use Tocris products. Selected citations for EGCG include:

11 Citations: Showing 1 - 10

  1. Evaluation of Glutaminolysis in T Cells.
    Authors: Warren Et al.
    Curr Protoc  2022;2:e540
  2. EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses.
    Authors: Michael F Et al.
    Pharmaceuticals (Basel)  2021;14
  3. Distinguishing the Effect on the Rate and Yield of Aβ42 Aggregation by Green Tea Polyphenol EGCG.
    Authors: Zhefeng Et al.
    ACS Omega  2020;5:21497-21505
  4. The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of α-Synuclein Amyloid Fibril Formation.
    Authors: Rainer Et al.
    Int J Mol Sci  2020;21
  5. The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo.
    Authors: C Et al.
    Neurobiol Dis  2020;138:104791
  6. Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.
    Authors: Daniels Et al.
    Sci Rep  2019;9:2937
  7. The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG.
    Authors: Tomas Et al.
    Biomolecules  2019;9
  8. Aβ42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism.
    Authors: Xue Et al.
    R Soc Open Sci  2019;6:190179
  9. Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine.
    Authors: Wei Et al.
    Nutrients  2019;11
  10. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
    Authors: Kottakis Et al.
    Nature  2016;539:390

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