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Potent cdk4 and cdk6 inhibitor; brain penetrant
Cdk inhibitor; potently inhibits cdk1 and cdk2; also inhibits CK1; acts as molecular glue
SETD8 inhibitor; also CDK4 inhibitor
Potent and selective CDK7 inhibitor; induces cell cycle arrest
GSK-3β inhibitor; also inhibits cdks
Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Potent, selective Cdc25 phosphatase inhibitor
Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Cdk inhibitor; potently inhibits cdk2 and cdk9
Cdk inhibitor; potently inhibits cdk9; also inhibits MK2
Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B
Potent CK1 inhibitor; also inhibits cyclin-dependent kinases
Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9
Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9
Potent and selective cdk inhibitor; orally bioavailable
Cdk inhibitor; potently inhibits cdk1 and cdk2
Cdk8 inhibitor; enhances IL-10 production
Potent and selective Cdk9 Degrader (PROTAC®)
Potent and selective ATP-competitive CDK9 inhibitor
Selective Cdk6 Degrader (PROTAC®)
Selective Cdk4 Degrader (PROTAC®)
Selective Cdk4/6 Degrader (PROTAC®
Dual cdk4/cdk6 inhibitor; orally bioavailable
Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members
Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome
Potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9
Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture
Potent and selective PKMYT1 inhibitor
Potent and selective CDKL5 inhibitor