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YKL 5-124

Catalog #: 7157 Datasheet
Catalog # Availability Size / Price Qty
7157/5
YKL 5-124 | CAS No. 1957203-01-8 | Cyclin-dependent Kinase Inhibitors
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Description: Potent and selective CDK7 inhibitor; induces cell cycle arrest

Chemical Name: N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

Purity: ≥95%

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Biological Activity

YKL-5-124 is a potent and selective CDK7/Mat1/CycH and cyclin dependent kinase (CDK7) inhibitor (IC50 values = 9.7 nM and 53.5 nM, respectively). YKL-5-124 shows 100-fold selectivity over CDK9 and CDK2. YKL-5-124 induces cell cycle arrest at the G1/S transition, inhibits E2F-driven gene expression and inhibits CDK1 and CDK3 T-loop phosphorylation.

Technical Data

M.Wt:
515.62
Formula:
C28H33N7O3
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1957203-01-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

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