AZD 5438
Chemical Name: 4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
Purity: ≥99%
Biological Activity
AZD 5438 is a potent inhibitor of cyclin dependent kinases (cdks; reported IC50 values are 6 - 45, 14, 16 and 20 nM for cdk2, cdk5, cdk1 and cdk9 respectively). Also inhibits cdk4 and cdk7 in the sub micromolar range. Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2 and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.
Byth et al.
Mol.Cancer Ther., 2009;8:1856 -
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
J.Med.Chem., 2018;61:9105
Product Datasheets
Citations for AZD 5438
The citations listed below are publications that use Tocris products. Selected citations for AZD 5438 include:
4 Citations: Showing 1 - 4
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AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins.
Authors: Helen Et al.
Sci Rep 2023;13:8334
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Translational and post-translational control of human naïve versus primed pluripotency.
Authors: Cheng Et al.
iScience 2022;25:103645
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A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.
Authors: Goonesekere Et al.
PLoS One 2014;9:e93046
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Functional characterization of the 19q12 amplicon in grade III breast cancers.
Authors: Natrajan Et al.
Breast Cancer Res 2012;14:R53
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