Home / Cyclin-dependent Kinase Inhibitors / FMF-04-159-R

FMF-04-159-R

Catalog #: 7159 Datasheet
Catalog # Availability Size / Price Qty
7159/10
FMF-04-159-R | CAS No. 2741262-15-5 | Cyclin-dependent Kinase Inhibitors
1 Image
Description: Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14

Chemical Name: N-(1-((3-(4-(Dimethylamino)butanamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

FMF-04-159-R is a potent inhibitor of CDK16 and CDK14 (IC50 values are 6 and 140 nM, respectively in kinase activity assay; IC50 = 563 nM for CDK14 in BRET assay). Also binds CDK2 (IC50 = 493 nM). Inhibition reversible upon compound wash-out. Control for FMF-04-159-2 (Cat. No. 7158).

Technical Data

M.Wt:
685.02
Formula:
C28H32Cl3N7O5S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2741262-15-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of covalent CDK14 inhibitors with pan-TAIRE family specificity.
    Ferguson et al.
    Cell Chem.Biol., 2019;26:804

Product Datasheets

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for FMF-04-159-R

There are currently no reviews for this product. Be the first to review FMF-04-159-R and earn rewards!

Have you used FMF-04-159-R?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.