CRBN: Products

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BDY FL Thalidomide

High affinity fluorescent probe for TR-FRET cereblon binding assay

Lenalidomide 5'-amine

Cereblon ligand with terminal amine for onward chemistry

Phenyl-glutarimide 4'-piperazine

Piperazine-functionalized cereblon ligand for PROTAC development

HHP 9

BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor

JB 300

Aurora A Degrader (PROTAC®)

EM 12-FS

Molecular glue; induces degradation of NQAT1

EM12-SO2F

Potent covalent inhibitor of Cereblon

BDY FL Lenalidomide

Fluorescent cereblon ligand

PD 4'-oxyacetic acid

Functionalized cereblon ligand for PROTAC development

PD 4'-piperazine

Stable cereblon ligand, for PROTAC synthesis

Pomalidomide 5'-piperidine-acid

Cereblon ligand with piperidine linker and terminal acid for onward chemistry

Pomalidomide 4'-alkylC6-amine

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Pomalidomide 4'-PEG5-amine

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 5'-amine-alkylC6-amine

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

PAG 3'-fluoro-4'-piperazine

Functionalized cereblon ligand for PROTAC development

PAG 3'-piperazine

Functionalized cereblon ligand for PROTAC development

PAG 3'-piperazine-4-methylpiperidine

Cereblon ligand with terminal piperidine for onward chemistry

PAG 4'-piperazine

Functionalized cereblon ligand for PROTAC development

PROTAC®(H-PGDS)-7

Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)

PROTAC®(H-PGDS)-8

Negative control for PROTAC®(H-PGDS)-7 (Cat. No. 8004)

α-Synuclein Degrader 2b

α-synuclein Degrader (PROTAC®)

STING Degrader SP23

Selective STING Degrader (PROTAC®)

STING Degrader N-Me-SP23

Negative control for STING Degrader SP23 (Cat. No. 8053)

JQ dS-4

BRG1/SMARCA4 Degrader (PROTAC®)
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