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EM12-SO2F

Catalog #: 7852 Datasheet
Catalog # Availability Size / Price Qty
7852/10
EM12-SO2F | CAS No. 2803819-61-4 | CRBN
1 Image
Description: Potent covalent inhibitor of Cereblon

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride

Purity: ≥95%

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Biological Activity

EM12-SO2F is a potent covalent Cereblon (CRBN) inhibitor (IC50 = 0.88 nM). Binds to a histidine residue (His353) in the IMiD binding pocket of CRBN and blocks the recruitment of its substrates. EM12-SO2F prevents Lenalidomide (Cat. No. 6305)-induced degradation of the zinc finger transcription factor IKZF1 in MOLT4 cells. It complements CRBN based PROTAC and genetic methods to validate CRBN-mediated degradation.

Technical Data

M.Wt:
326.3
Formula:
C13H11FN2O5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2803819-61-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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